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Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach

Recruitingn/aAges 18 Years - 50 YearsAllCharite University, Berlin, Germany
NCT05334888 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors. It will follow 200 healthy transgender individuals for five years during their hormone replacement therapy (HRT) and analyze them for the possible emergence of cardiovascular risk factors in relation to changes in the gut microbiome, metabolome, and immunome. We would also like to phenotype cardiovascular disease.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-50 * Language requirements: German, English * Previous gender hormone replacement therapy (HRT). * Ability to give consent and written consent to participate. * Health insurance (for clarification of incidental findings) Exclusion Criteria: * Diseases or functional disorders that, in the opinion of the study physician, preclude participation in the study. * Incapacity or other circumstances that do not allow study participants to fully understand the nature, significance and scope of this study.
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What it tests

  • Not listed
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Where

1 site
Experimental and Clinical Research Center, Clinical Research Unit
Berlin, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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