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Neural Connectivity During Therapy for Adolescent PTSD

RecruitingNAAges 12 Years - 17 YearsAllThe University of Texas Health Science Center at …
NCT05423444 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ages 12-17 and Tanner stage 2 or above * history of interpersonal trauma * PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month Exclusion Criteria: * current or past use of psychiatric medications * severe suicidal/homicidal ideation * current hospitalization * other current psychotherapy or previous treatment with TF-CBT * history of head injury with loss of consciousness for \>5 minutes * IQ\<85 * major medical illness * MRI contraindications (metal in body; braces on teeth) * psychosis, bipolar 1, autism, developmental disorder, panic disorder * first-degree family member with diagnosis of psychosis or bipolar I disorder * substance dependence within the past 3 months or current drug use that is frequent
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What it tests

  • TF-CBT
  • TAU
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Where

1 site
UT Health Department of Psychiatry
San Antonio, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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