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CBT and the Neural Circuits of Anxiety

Recruitingn/aAges 18 Years - 64 YearsAllUCLH/UCL Joint Research Office
NCT05549102 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions. This study aims to provide a theoretical model of the neurobiological mechanisms of CBT's therapeutic effect, where there currently is none, and potentially allow for more targeted/specific approaches to anxiety disorders following the identification of key CBT mechanisms. The ultimate aim is to improve the efficacy of CBT, and more generally, psychological interventions for anxiety disorders.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Enrolled in IAPT Step 3 (high intensity service) * Score of or above 8 on the GAD-7 (indicating moderate anxiety on a standard scale of anxiety; Spitzer et al., 2006) * Willing and able to provide written consent Exclusion Criteria: * Score above 22 on the GAD-7 * Past/present psychotic disorder, bipolar disorder/mania or alcohol/substance use disorder (outside a comorbid psychiatric episode) * History of medical illness that may impair cognitive function (e.g. serious head injury, endocrine disorder) * Current psychotropic pharmacological intervention (e.g. SSRIs) or use within 3 months * MRI contraindications such as pacemaker, aneurysm clip, cochlear implant, neurostimulator, IUD, shrapnel, metal fragments in eye, weight of above 250lbs or claustrophobia * Females who are pregnant, planning pregnancy, or breastfeeding
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What it tests

  • Cognitive Behavioural Therapy
  • Waiting List
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Where

1 site
Institute of Cognitive Neuroscience, University College London
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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