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Disrupting Fear-based Memory Consolidation

RecruitingNAAges 18 Years - 65 YearsAllEmory University
NCT05560113 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ability to provide informed consent * Willingness to participate in study * No history of musculoskeletal impairment or neurological disease * Clinical diagnosis of PTSD for individuals in the PTSD group. Exclusion Criteria: * Any participant outside the age range * Participants that show signs of dementia (score \< 20 on the Montreal Cognitive Assessment) * Participants that have a history of major head trauma, a neurodegenerative disorder, or recent (\<6 months) substance abuse; * Participants that had a recent history of Central Nervous System (CNS) active drugs that may influence cortical excitability or learning; or * Participants that report contraindications to TMS or MRI - if participating in the TMS/MRI experiments * Current psychoactive medication usage * Current symptoms of psychosis or bipolar disorder (as indicated by study staff through a clinical interview as part of that study). * The study will exclude adults unable to consent, individuals who are not yet adults, pregnant women and prisoners on scientific grounds and to minimize risk.
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What it tests

  • Continuous theta burst stimulation (cTBS)
  • Sham continuous theta burst stimulation (cTBS)
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Where

2 sites
Emory Rehabilitation Hospital
Atlanta, United States
Emory University Hospital
Atlanta, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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