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Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve

RecruitingNAAges 18 Years - anyAllUniversity College, London
NCT05664854 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Electroceuticals is a new field in which the goal is to treat a wide variety of medical diseases with electrical stimulation of autonomic nerves. A prime target for intervention is the cervical vagus nerve as it is easily surgically accessible and supplies many organs in the neck, thorax and abdomen. It would be desirable to stimulate selectively in order to avoid the off-target effects that currently occur. This has not been tried in the past, both because of limitations in available technology but also because, surprisingly, the fascicular organisation of the cervical vagus nerve is almost completely unknown. The aim of this research is to investigate the functional anatomy of fascicles in the cervical vagus nerve of humans. This will include defining innervation to the heart, lungs and recurrent laryngeal and, if possible, the oesophagus, stomach, pancreas, liver and gastrointestinal

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age over 18 * Written informed consent by patient or proxy * Clinical diagnosis of disorder affected directly or indirectly or will possibly respond to vagus nerve stimulation Exclusion Criteria: * Aged 17 and below * Unfortunately, it is unlikely that interpreters of all languages will be available in the unit so persons who cannot understand verbal explanation in English and for whom we could not find a suitable consultee would have to be excluded from the study.
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What it tests

  • Nerve cuff electrodes for spatially selective vagus nerve stimulation and electrical impedance tomography
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Where

1 site
National Hospital of Neurology and Neurosurgery
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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