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โ† Trials
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South China Children Cancer Group - Relapsed-Acute Lymphoblastic Leukemia 2022 Protocol

RecruitingPhase 4Ages 1 Year - 14 YearsAllSun Yat-Sen Memorial Hospital of Sun Yat-Sen Univโ€ฆ
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In plain words

What the trial is, and whether it could suit you

In recent years, the prognosis of pediatric relapsed ALL patients has improved, but the 5-year OS of patients with first recurrence is still less than 50%. A number of in vitro studies have shown that arsenic trioxide (ATO) can selectively inhibit the growth and induce apoptosis in a variety of leukemia cell lines, suggesting that ATO as a synergist combined with other common chemotherapy drugs may provide a new target for the treatment of relapsed ALL. Realgar Indigo naturalis formula is a compound traditional Chinese medicine preparation developed in China. The main component of realgar is arsenic tetrasulfide (As4S4), which can produce similar pharmacological effects to ATO. Based on the R3 protocol, this study plans to perform a double-blind randomized controlled trial, and to randomly combine compound Huangdai tablets with compound Huangdai tablets in the treatment of intermediate a

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * B or T cell type; * the first recurrence; * the risk stratification was medium or high risk. Exclusion Criteria: * mature B cell leukemia; * acute mixed phenotype leukemia; * patients with positive BCR/ABL fusion gene; * the second tumor * definite CML blast crisis; * ALL with Down's syndrome.
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What it tests

  • Realgar Indigo naturalis formula
  • Conventional chemotherapy
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Where

1 site
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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