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โ† Trials
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Chronotherapy for Depressive Episodes

RecruitingNAAges 18 Years - 100 YearsAllSt. Olavs Hospital
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In plain words

What the trial is, and whether it could suit you

Evidence-based treatments for depression, such as antidepressive medication, usually have a latency of 4 to 6 weeks before they achieve a therapeutic effect. Chronotherapy is a group of non-pharmacological interventions that presumably act on the circadian system to achieve a rapid-onset clinical effect and better long-term effects and has been shown efficient to improve depressive symptoms. Interventions include sleep deprivation, sleep-phase advancement and stabilization, and light therapy. There are few studies testing the effectiveness of combining these three chronotherapeutic techniques in the initial phase of treatment of depression in a mental health care clinic. The investigators aim to test the effects and safety of chronotherapy in addition to TAU compared to TAU alone, with the primary outcome being self-reported depressive symptoms at 1 week following randomization. The stud

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria. Patients eligible for the trial must comply with all the following at randomization: * Being 18 years or older * Willing and able to provide a written informed consent * Newly diagnosed with an ongoing moderate or severe depressive episode according to the International Classification of Disorders 10th edition (ICD-10) and accepted for treatment for the depressive episode. The diagnosis is set in consensus of a licensed therapist and a specialist in psychiatry/psychology. * The patient must score โ‰ฅ 9 on the Hamilton Depression Rating Scale-6. * Must be able to communicate in a Scandinavian language Exclusion criteria. Patients are considered ineligible for participation if any of the following are present: * Illnesses and treatments where chronotherapy may be contraindicated (for example epilepsy, ongoing attack of multiple sclerosis, blindness, narcolepsy and psychotic depression, ECT treatment). * Known pregnancy. * Individuals with a known diagnosis of emotionally unstable personality disorder (F60.3). * Individuals with a known psychotic disorder * Shiftwork or other related social or work circumstances that inhibit participation * Participation in an ongoing trial at the outpatient clinic that encompasses digital cognitive behavior therapy for insomnia (recruitment to this trial will end in 2023).
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What it tests

  • Chronotherapy
  • Treatment as usual
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Where

1 site
St. Olavs Hospital, Nidaros DPS
Trondheim, Norway
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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