๐ฌIn plain words
What the trial is, and whether it could suit you
Rhizarthosis is a common disease in the population (15%). It has a major impact on the function of the hand since it compromises the pollicidigitales claws and all gripping functions with the thumb. However, no curative medical treatment exists to date. The treatment is initially based on a symptomatic approach: analgesics, non-steroidal anti-inflammatories, immobilization orthoses or even intra-articular injections of corticosteroids or hyaluronic acid. When it is exceeded, surgical treatment is considered. This is also not a curative treatment. Indeed, the 3 types of main interventions proposed (arthrodesis, arthroplasty or trapezectomy) each have significant consequences for the patient: stiffness for the arthrodesis, risk of dislocation or failure of the material for the prosthesis, long consequences for the trapezectomy. , or potential complications of surgery.
Stem cell-based ther
Sign in to get the eligibility rules as simple questions to take to your doctor.
๐ Eligibility rules (as published)
Inclusion Criteria:
* Rhizarthrosis DELL stage 1 to 3
* Symptomatic medical treatment for a period of at least 6 months (analgesic, orthosis, anti-inflammatory, etc. or intra-articular infiltration of the trapezio-metacarpal joint) which has become ineffective (surgical stage)
* EVA pain โฅ 4
* Quick Dash or PRWHE โฅ 20/100
* Affiliation to a social security scheme
* Person who has read and understood the information letter and signed the consent form
Exclusion Criteria:
* History of intra-articular injection of the trapezio-metacarpal (corticoid or hyaluronic acid) in the last 6 months
* Body Mass Index \< 18 kg/m2
* Contraindication to general or local anesthetics including XYLOCAINE 10 mg/mL ADRENALINE 0.005 mg/mL, solution for injection
* Contraindication to sedation or general anesthesia (left to the discretion of the anesthesiologist)
* Contraindication to liposuction (eg bleeding disorder)
* Documented severe allergy to conventional antibiotics such as ฮฒ-lactams, cyclins, macrolides, quinolones, aminoglycosides, etcโฆ
* Known hypersensitivity to human albumin or to any of the excipients (VIALEBEX 200 g/L, solution for infusion)
* A general or local infection near the sampling or injection sites
* Any surgery scheduled over the duration of the study of the hand (carpal tunnel type operation) or upper limb that may have an impact on the assessment of pain and/or functional indices
* Persons on immunosuppressants: corticosteroid therapy \> 10 mg/d, methotrexate \> 25 mg/week, mycofenolate mofetil \> 3 grams/d, azathioprine \> 200 mg/d and intravenous cyclophosphamide and any biotherapy in the 90 days preceding the medical visit. inclusion
* Congenital or acquired immune deficiency
* Prescription of a new systemic treatment that may influence the condition of the hand (vasodilator or immunosuppressant) in the 90 days preceding inclusion
* Persons infected with HIV, HCV, HBV, HTLV and syphilis
* Contraindication to MRI, (eg, due to presence of pacemakers or other incompatible foreign material or claustrophobia)
* Contraindication to the injection of gadolinated contrast product (gadolinium) for performing MRI (history of hypersensitivity to gadolinated contrast products)
* Active COVID-19 infection (PCR positive)
* Any cardiovascular, metabolic, endocrine, psychiatric or cancerous pathology in uncontrolled evolution
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