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The Metabolic Effects of Intermittent Fasting

RecruitingNAAges 21 Years - 45 YearsAllUniversity of Pittsburgh
NCT05722873 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Caloric restriction has beneficial metabolic effects in humans including weight loss and improvement in blood pressure and lipid levels. Intermittent fasting has emerged as a popular alternative to caloric restriction as it does not require daily adherence to a dietary protocol, but whether the benefits of fasting protocols are dependent on weight loss is not known. In this study, the investigators will explore the metabolic effects of fasting and evaluate whether these effects, including negative effects on bone metabolism, are independent of weight loss.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Men and women, ages 21-45 years 2. BMI of at least 21 kg/m2 and up to and including BMI of 29 kg/m2 3. Normal thyroid function 4. Regular menses (women) 5. At least one first-degree relative with type 2 diabetes (T2D) and/or history of gestational diabetes Exclusion Criteria: 1. Any chronic diseases including hypertension and Type 2 diabetes mellitus 2. Indication for lipid-lowering therapy in non-diabetics, using the more stringent AHA guideline cutoff (LDL\>190 or an estimated 10-year ASCVD risk of \>7.5%) 3. Chronic medications, including oral contraceptive pills 4. Pregnant and/or breastfeeding 5. History of an eating disorder 6. 25-OH vitamin D level \< 20 ng/mL 7. Active substance abuse, including alcohol 8. Subjects with a prior history of intermittent fasting 9. The study physician feels that the subject may not be able to safely complete the protocol or may place themselves at risk by undergoing the protocol
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What it tests

  • Fasting arm
  • Weight maintenance
  • Counseling
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Where

1 site
University of Pittsburgh
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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