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EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

RecruitingPhase 1Ages 18 Years - anyAllNYU Langone Health
NCT05723107 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a single arm study in the treatment of pancreatic ductal adenocarcinoma (PDAC). The investigators propose to test the tolerability of chemotherapy plus endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) using the RF Electrode in patients receiving palliative second or third line therapy for unresectable non-metastatic pancreatic cancer.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed and histologically confirmed PDAC by biopsy * Axial CT scan or MRI consistent with PDAC with at least 1 cm in greatest diameter * ECOG performance status 0-2 * Patients with locally advanced PDAC, who have not responded or progressed on first line chemotherapy, are deemed not resectable based on multidisciplinary review, and show no evidence of distant metastasis * Lesions between 1 - 4cm in size Exclusion Criteria: * Patients that show evidence of distant metastasis * Endoscopically non-accessible mass * Pregnant patients * Inability to provide informed consent * Lesions \<1cm, or \>4cm in greatest diameter
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What it tests

  • Chemotherapy
  • Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA)
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Where

1 site
Tisch Hospital
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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