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Atezolizumab and Bevacizumab Plus TACE-HAIC for Unresectable Advanced HCC: a Phase 2 Clinical Trial

RecruitingPhase 2Ages 18 Years - 75 YearsAllSun Yat-sen University
NCT05751343 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atezolizumab and bevacizumab was approve for advanced unresectable hepatocellular carcinoma (aHCC). Whether the additional of transartial chemobolization and hepatic artery infusion chemotherapy will improve the response rate for those patients is still unknown. This phase 2 clinical trial aims to investigate the objective response rate for unresectable advanced hepatocellular carcinoma.

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📋 Eligibility rules (as published)
Inclusion Criteria: * (a) patients were diagnozied with unresectable advanced-stage HCC, * (b) Child-Pugh A or B liver function; * (d) Eastern Cooperative Oncology Group (ECOG) performance status 0-1; * (e) adequate hematologic blood counts (white blood cell count \>3ⅹ109/L, absolute neutrophil count \>1.5ⅹ109/L, platelet count \>10ⅹ109/L, hemoglobin concentration \>85 g/L); Exclusion Criteria: * (a) severe underlying cardiac, pulmonary, or renal diseases; * (b) history of a second primary malignant tumor; * (c) contraindication to either atezolizumab and bevacizumab.
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What it tests

  • TACE-HACI, plus atezolizumab-bevacizumab
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Where

1 site
Sun Yat-sen University Cancer Center
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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