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Memory and Social Interactions

Recruitingn/aAges 18 Years - 85 YearsAllUniversity Hospital, Caen
NCT05800028 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Memory and social interaction are intimately linked. On the one hand, social interaction is a privileged context for learning, and on the other hand, appropriate social interactions involve remembering the partners encountered and previous exchanges. People with Alzheimer's disease classic syndrome variant (AD) have a major impairment of episodic memory, while people with the semantic variant of primary progressive aphasia (SPPA) are characterized by semantic disorders in the foreground, associated with changes in their social behavior with a tendency to egocentricity. In both cases, patients frequently have reduced social interactions. Although social interaction situations seem to constitute a privileged learning context, their effectiveness for patients with cognitive disorders must be evaluated and the conditions under which they are effective must be established. The main objective

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📋 Eligibility rules (as published)
Inclusion criteria: * AD group: Age between 50 and 85 years, Diagnosis of probable Alzheimer's disease dementia with amnestic presentation and documented decline following the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. * SPPA group: Age between 50 and 85 years, Diagnosis of the semantic variant of primary progressive aphasia following the classification of primary progressive aphasia and its variants. * HC group: Age between 50 and 85 years, Matched in age and sociocultural status with one of the AD or SPPA patients, No cognitive complain, No recent reduction in social or cognitive activities, No contraindication to MRI examination. * Partners: Age over 18 years of age , No cognitive complaints, Social interactions of at least two hours per week for at least 5 years with one of the individuals of the other three groups. Exclusion criteria (for all groups): * Deprivation of liberty by judicial or administrative decision * Not being a member of a social security system * Concurrent participation in a therapeutic drug trial * Uncorrected visual and/or auditory disorders that are sufficiently significant to interfere with the protocol * History of neurological disorders (stroke, epilepsy, head trauma with loss of consciousness for more than one hour) * History of chronic alcoholism or drug abuse * History within the last 10 years of a clinically significant major psychiatric disorder * Cancer within the past 5 years, except for squamous cell carcinoma * Use of medications that may affect cognitive and/or brain function. Given the number of molecules involved and the dosages, the principal investigator will judge on a case-by-case basis whether regular use of certain medications will interfere with the study
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What it tests

  • Learning new information
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Where

1 site
Caen University Hospital
Caen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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