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Observational Dutch Young Symptomatic StrokE studY - nEXT

Recruitingn/aAges 18 Years - 50 YearsAllRadboud University Medical Center
NCT05853796 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

BACKGROUND: Worldwide, 2 million patients aged 18-50 years suffer an ischemic stroke each year with an increasing trend over the past decade due to yet unknown reasons. Whereas prognosis and antithrombotic treatment in older patients with cardiovascular disease are among the best studied topics in clinical medicine, this does not hold true for patients at young age. It is of great importance to treat these patient groups correctly to prevent recurrence and bleeding complications. However, previous research have shown that there is a long-term increased risk of recurrent ischemic events despite the secondary prevention and a subsequent increased bleeding risk. To tailor effective antithrombotic therapy to the individual patient, it is essential to understand the underlying pathogenesis and identify modifiable risk factors in young patients for recurrence or bleeding. It is thought that ab

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with a first-ever transient ischemic attack (TIA) or acute ischemic stroke aged between 18 and 50 years old * For this study, acute stroke is defined as "occurence of acute neurological deficit lasting more than 24 hours, with confirmation on imaging (CT(-a) or MR(-a))".TIA is defined as "occurence of acute neurological deficit lasting less than 24 hours with confirmation of ischemia on MRI). * Patients have a kidney function eGFR\>30ml/min. Exclusion Criteria: * A history of clinical TIA, ischemic stroke or intracerebral hemorrhage * A intracerebral hemorrhage resulting from trauma, known aneurysm or underlying intracerebral malignancy. * A venous infarction, retinal infarction or amourosis fugax. * Inadequate control of the Dutch language to reliably sign an informed consent from and/or participate in the follow-up * Patients are excluded if they have a contra indication for 3T MRI.
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What it tests

  • Not listed
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Where

6 sites
Radboudumc
Nijmegen, Netherlands
Catharina Ziekenhuis
Eindhoven, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
Isala
Zwolle, Netherlands
HagaZiekenhuis
The Hague, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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