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The Role of the Brain in Mental and Physical Fatigue

RecruitingPhase 3Ages 18 Years - 35 YearsAllVrije Universiteit Brussel
NCT05880342 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine the role of brain neurotransmission in the onset of fatigue, identify the brain areas involved, and determine how brain activity and neuromuscular efficiency changes during onset of fatigue. Three different experimental studies (physical fatigue, mental fatigue and combined) will be performed with a randomized, single-blinded, placebo controlled, counter-balanced, cross-over design. The objectives of the projects are as follows: * To experimentally assess the role of a dopamine, and a noradrenalin reuptake inhibitor in the onset of exercise-induced fatigue * To identify changes in brain activation associated with altered PF and fatigue perception * To experimentally assess the effect of a NA or DA reuptake inhibitor on MF, brain activation and the sources of changes in brain activation * To experimentally assess the role of brain neurotra

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy trained individuals (exercises at least 1x per week, no neurological, cardiovascular internal or musculoskeletal disorders of any kind) * No use of chronic or occasional prescribed medication (except for contraceptives) * Non-smoker Exclusion Criteria: * Injuries of any kind in the past 6 months * Pregnancy * Specific food or drink allergies (e.g. lactose and/or gluten intolerance) * Suffering from a chronic health condition (could be neurological, cardiovascular, internal and musculoskeletal) * Participating in any concomitant care or research trials * History of suffering from any mental/psychiatric disorders: Suffering from a higher risk of burn out, indicated by a total score of more than 2.59 on the Burn out assessment tool (BAT) Suffering from high general fatigue, indicated by a score of more than 57 on the Multidimensional fatigue inventory (MFI) Suffering from depression, indicated by a score of more than16 on the Beck depression inventory-II (BDI-II) * Use of medication Chronic use with an exception for contraceptives Prescribed medication in between or before trials Use of non-prescribed occasional medication 24 hours prior each trial * Use of caffeine and heavy efforts 24 hours prior each trial * Suffering from colour vision deficiencies * Not eating a standardized meal, the morning of each trial
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What it tests

  • Reboxetine Pill
  • Methylphenidate Oral Product
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Where

1 site
Brussels Labo voor Inspanning & Topsport U-residence
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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