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The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.

RecruitingNAAges 18 Years - 85 YearsAllUniversity of Oxford
NCT05942287 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study looks at the effects of weight loss in people who have heart failure with reduced ejection fraction (HFpEF) and are overweight or obese. The main questions it aims to answer are whether weight loss in this group of people improves: * The heart's shape and how well it pumps blood * The person's quality of life and how much they can exercise Participants will attend 2 study visits, separated by 3-6 months. The intervention period takes place in between the 2 study visits. Each study visit may involve measurements including: Symptom and quality of life questionnaires Body measurements such as height and weight Blood tests Ultrasound scans of the heart (echocardiogram) Magnetic Resonance Imaging (MRI) scans of the heart 6 minute walk test Participants are randomly allocated (in other words, by lottery) to either 'diet' or 'control' groups. The control group will continue stan

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📋 Eligibility rules (as published)
Inclusion Criteria: * Heart failure determined by left ventricular ejection fraction 20-45% * Body mass index \> 27.5kg/m\^2 Exclusion Criteria: * Contraindications to magnetic resonance imaging * NYHA class IV * Pregnancy, planned pregnancy or lactating * Significant valvular, ischemic, infiltrative or other potentially confounding cardiac disease * Any other conditions which may potentially compromise the safety or scientific validity of the study
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What it tests

  • Diet intervention
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Where

2 sites
Jersey General Hospital
Jersey, Jersey
Jenny Rayner
Oxford, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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