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โ† Trials
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Lumbar Vein Embolization for Chronic Headaches With Nutcracker Physiology

RecruitingNAAges 18 Years - anyAllMayo Clinic
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In plain words

What the trial is, and whether it could suit you

The purpose of this research is to gather information on the safety and feasibility of coiling the lumbar vein for the treatment of chronic headaches in patients with Nutcracker physiology and retrograde lumbar vein flow with epidural venous plexus congestion. All patients are extensively evaluated by a headache trained Neurologist confirming high pressure headache refractory to other treatments.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Daily headache from onset lasting \> 3 months. * Headache described as pressure sensation. * Headache worsened in the Trendelenburg position. * Exposed to CSF pressure/volume lowering medications. * Tried 2 of 4 unless contraindications: acetazolamide, methazolamide, indomethacin SR or spironolactone) or CSF volume removal via LP with positive or neutral response. * Failed at least 3 typical headache preventative medications from different classes-antidepressants, antiepileptic, blood pressure medications. * MRI demonstrates that Nutcracker physiology is present. * Decreased SMA angle, renal vein narrowing, decreased AMD. * Retrograde lumbar vein flow and early EVP enhancement. * Ability to understand study procedures and to comply with them for the entire length of the study. * Negative pregnancy test. Exclusion Criteria: * Evidence of disc edema. * Positive urinalysis for hematuria or proteinuria. * Abnormal CBC or CMP. * MRI, MRA head and neck and MR venogram with a possible secondary causes of headache including space occupying lesions, Chiari malformation, cerebral vein thrombosis, hydrocephalus, dissection, aneurysm etc.
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What it tests

  • Coil Embolization of the Lumbar Vein
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Where

1 site
Mayo Clinic Florida
Jacksonville, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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