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โ† Trials
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The Beneficial Value of PET/CT in the Follow-up of Stage III Non-small Cell Lung Cancer Patients

RecruitingNAAges 18 Years - anyAllRadboud University Medical Center
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In plain words

What the trial is, and whether it could suit you

The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F-Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography (18F FDG PET/CT) versus follow-up with conventional CT surveillance. Participants will receive usual care until 3 years of follow-up (control group) with additional whole-body 18F FDG PET/CT scans during follow-up visits at 6 months, 12 months, 18 months, 24 months, and 36 months of follow-up in the intervention group. Other tasks include: * filling in quality of life (QOL) questionnaires at every time point; * participating in an interview evaluating the addition of the 18F FDG PET/CT scans (optional); * collecting blood at the follow-up time points for our secondary endpoint (optional). Researchers will compare the usual care control group with the intervention group

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Eligible for this study are patients with stage III NSCLC (8th edition TNM Classification) who (are about to) start(ed) follow-up care (which may include adjuvant treatment) at a participating hospital. Patients may already be included during their curative intent treatment. Patients enter a screening period that runs until their randomization. Inclusion Criteria: To be eligible to participate in this study, a subject must meet all of the following criteria at the timing of randomization: * Cytological or histologically proven stage III non-small cell lung cancer before start of curative intent treatment * Treated with curative intent and started follow-up care * All adjuvant treatments are permitted as co-intervention during follow-up care * Age 18 years or older * ECOG Performance Status classification 0-2 at moment of inclusion * Written and signed informed consent by the patient or patient's representative (with the understanding that consent may be withdrawn by the patient or patient's representative at any time without consequences to future medical care) Exclusion Criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: * Life expectancy shorter than 6 months at the end of curative intent treatment * Evidence of recurrence after end of curative intent treatment and before randomization (4 months follow-up) * Any condition that, in the opinion of the investigator, would interfere with evaluation of the intervention or interpretation of HRQOL or other study results.
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What it tests

  • 18F FDG PET/CT
  • CT scan
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Where

27 sites
Tergooi MC
Hilversum, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
Antoni van Leeuwenhoek/Nederlands Kanker Instituut
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
Gelre Ziekenhuizen
Apeldoorn & Zutphen, Netherlands
Amphia Ziekenhuis
Breda, Netherlands
Deventer Ziekenhuis
Deventer, Netherlands
Ziekenhuis Gelderse Vallei
Ede, Netherlands

โ€ฆand 19 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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