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Study of Brain-Gut Function Reconstruction After Intersphincteric Resection for Ultra-Low Rectal Tumors

UnknownNAAges 18 Years - 75 YearsAllHuashan Hospital
NCT06082648 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To investigate the effects of intersphincteric resection (ISR) of ultra-low rectal tumor on the brain-rectoanal function of patients, and to precisely localize the cerebral functional regulatory regions for intervention targets of anorectal remodeling. Utilizing transcranial magnetic stimulation(TMS) technology to explore the functional remodeling of the "new" anorectal muscle groups and provide a theoretical basis for more research on the rehabilitation and mechanism of fecal incontinence.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Primary ultra-low rectal tumor patient who is received intersphincteric resection and preventive ileostomy was performed. * Patient who is willing to participate in the study, and voluntarily sign informed consent. Exclusion Criteria: * Anastomotic leakage or other serious complications occur after surgery. * Advanced tumor, tumor recurrence or metastasis. * Patients with contraindications of fMRI scanning, such as history of metal implants in the body, claustrophobia, etc. * Patients with contraindications for TMS treatment, such as intracranial metal implants, epilepsy history, heart disease with unstable heart function, retinal detachment, etc. * Combined with organic brain disease and drug abuse history. * Combined with other mental diseases. * Pregnant or lactating women.
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What it tests

  • Transcranial magnetic stimulation
  • Sham Transcranial magnetic stimulationt
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Where

1 site
Huashan Hospital Affiliated to Fudan University
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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