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Introduction of Y90-PET-CT Post Radioembolisation Therapy Scans

RecruitingNAAges 18 Years - 80 YearsAllThe Christie NHS Foundation Trust
NCT06123676 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Yttrium-90, attached to microspheres, usually referred to as 90Y-microspheres or Y-90 radioembolisation, can be used in some cases to treat patients with liver tumours or liver metastasis. The treatment aim is to infuse the 90Ymicrospheres into the patient's liver. The microspheres get trapped in the lesions of micro-blood vessels while the yttrium-90, a radioactive compound, delivers radiation doses locally at these sites and damages the diseased cells. Therapy is performed in such a way the 90Y-microspheres are localised in the tumour areas minimising damage to the healthy liver tissue. This treatment requires many steps involving professionals from different medical disciplines. Patients are scanned in the nuclear Medicine Department on a gamma camera the day after the treatment. This scan is referred as Y-90 bremsstrahlung-SPECT. This posttherapy scan provides a 3-dimensional (3D)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing liver treatment Y90-Microspheres therapy. * Male or female * Aged 18-85 years Exclusion Criteria: A participant will not be eligible for inclusion in this study if any of the following criteria apply: * History of, or suffers from, claustrophobia or participant feels unable to lie flat and still on their back for a period of up to 45 minutes in the scanner; o Priority will be given to their current clinical care scan Y-90-bremsstrahlung-SPECT * In the opinion of the clinical team, they are unlikely to comply with the study protocol and restrictions that it imposes (i.e. patient uncomfortable to withstand a double scan on the day); Female participants of childbearing potential must confirm they are not pregnant (a strict requisite before 90Y-therapy anyway).
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What it tests

  • Y90-PET-CT scan
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Where

1 site
The Christie NHS - Nuclear Medicine Department
Manchester, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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