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Breisgau PHENO-HEART MI

Recruitingn/aAges 18 Years - 85 YearsAllUniversity Hospital Freiburg
NCT06166407 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Coronary heart disease and its acute complication, myocardial infarction (MI), represent the leading causes of death in Europe and the United States. Although novel treatment strategies have helped to improve survival in patients with MI, a large proportion of patients develops heart failure and is at risk of life-threatening arrhythmias. Complications arising after MI constitute a severe burden not only for the patients themselves, but also for health care systems worldwide. The likelihood of these complications depends on the area of myocardial tissue lost and the process of myocardial repair and scar tissue formation after MI ('remodeling') which are modified by the local and systemic immune response after MI. The immune response is critical after myocardial infarction. In particular, sustained overactive and prolonged inflammatory reactions lead to accentuated myocardial damage and

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📋 Eligibility rules (as published)
Inclusion Criteria: * Emergency coronary angiography and age\>18 years and STEMI or NSTEMI or "none of these diseases" Exclusion Criteria: * Hemoglobin\<7,0 g/dl * Platelets \<50.000/µl * Unable to provide written informed consent * Age \> 80 years * hematological neoplasia * metastasized cancers * acute infection (z.B. Sepsis) * Chronic Inflammatory conditions (z.B. inflammatory bowel disease, Rheumatoid arthritis, chronisch hepatitis) * Pregnancy * Immunosuppression * Resuscitation \>5 min oder mehr als 1x Defibrillation vor Koronarangiographie * Cardiogenic shock * Mechanical circulatory support * Cardiomyopathy with an left ventricular ejection fraction F \<40% before the event * Dialysis * Cirrhosis \> CHILD-A * Not living in the county of Breisgau-Hochschwarzwald or Emmendingen oder planned relocation * Alcohol and drug abuse * Non-compliance
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What it tests

  • no intervention
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Where

1 site
Department of Cardiology and Angiology, Medical Center - University of Freiburg
Freiburg im Breisgau, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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