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Microbiome and Diet in Parkinson's Disease

RecruitingNAAges 40 Years - 80 YearsAllUniversity of British Columbia
NCT06207136 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia. Research has shown that eating components of Mediterranean diets are associated with a 30% lower risk to develop PD and a 40% lower mortality rate in those living with PD. Diet may influence the gut and microbiomes, thus may affect PD risk and progression. This study will examine how easy it will be to adhere to a certain type of diet for 18 months and what changes may occur in the gut microbiome and in PD symptoms on a specific diet during that time. The study will involve in-person study visits at UBC as well as online diet coaching sessions and online group cooking classes over Zoom. This is a randomized study, meaning that participants will be assigned by chance t

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📋 Eligibility rules (as published)
Inclusion Criteria: Eligible if the person living with Parkinson's has/is: 1. a clinical diagnosis of PD, 2. cognitively stable (no clinical dementia), 3. between 40-80 years old, 4. able to travel to UBC for 6 onsite visits over 18 months, 5. sufficient English proficiency (coaching and cooking classes are in English only), 6. on a stable dopaminergic medication for at least one month before baseline, 7. computer and internet access at home, and can be available via video link for at least 80% of the study sessions. Exclusion Criteria: Not eligible, if person has/is: 1. a diagnosis of atypical parkinsonism, 2. medical or psychiatric conditions that would prevent full participation in the nutrition intervention (such as food allergies), significant dysphagia, diabetes on insulin, anti-coagulation on warfarin, and inflammatory bowel disease, 3. clinical dementia, 4. unable to complete questionnaires or understand study instructions, 5. using of immunomodulatory agents, 6. used Probiotics in the last 4 weeks prior to study start, 7. used Antibiotics in the last 3 months prior to study start, 8. contraindications for MRI.
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What it tests

  • Mediterranean-style diet
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Where

1 site
UBC Pacific Parkinson's Research Centre
Vancouver, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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