Application of ICG@HSA Complexes in Fluorescence Image-Guided Laparoscopic Anatomical Liver Resection

Inclusion Criteria: 1. Age: 18-75 years old, patients with hepatic malignancies who are undergoing laparoscopic anatomical liver resection; 2. Preoperative liver function Child-Pugh grade A or B; 3. No contraindications for laparoscopic liver resection; 4. Expected survival ≥3 months; 5. ECOG PS score 0-1; 6. Normal major organ functions, and meet the following laboratory test results within 7 days prior to enrollment: white blood cell (WBC) ≥2.5×10\^9/L, absolute neutrophil count (ANC) ≥1.5×10\^9/L, platelet (PLT) ≥75×10\^9/L, hemoglobin (HGB) ≥90g/L; NR ≤1.5xULN; serum creatinine (CT) ≤1.5xULN; total bilirubin (TBI) ≤1.5×upper limit of normal (ULN); 7. Patients voluntarily participate and sign informed consent. Exclusion Criteria: 1. No obvious ischemic demarcation line after intraoperative occlusion or disconnection of target hepatic pedicle, or the liver fluorescence reaches an intensity that interferes with surgery before intraoperative ICG injection. 2. Poor hepatic reserve function (ICG R15 ≥ 20%); 3. Severe cardiopulmonary diseases, intolerant to general anesthesia and surgery; 4. Moderate or large amount of symptomatic ascites or pleural effusion; 5. Active bleeding or coagulation abnormalities; 6. Hepatic encephalopathy; 7. Allergy to ICG; 8. History of gastrointestinal bleeding within the past 6 months or definite tendency for gastrointestinal bleeding; 9. Severe esophageal gastric varices requiring interventional treatment; 10. Objective evidence showing severe impaired pulmonary function such as pulmonary fibrosis; 11. Any significant clinical and laboratory abnormalities that the investigator considers affecting safety assessment.