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DNA Methylation Markers in Veterans Exposed to Open Burn Pits

Recruitingn/aAges 25 Years - 70 YearsAllCentral Arkansas Veterans Healthcare System
NCT06305091 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: The VA and DoD estimate that 3.5 million Veterans and Service Members were exposed to open burn pits used for waste disposal during military deployments to countries such as Kuwait, Afghanistan, and Iraq since 1990. Since the lasting adverse effects of this exposure on health are unknown, the VA Airborne Hazards and Open Burn Pit Registry (AHOBPR) was created. More than 209,000 participants to date have answered the registry questionnaire about the extent of exposure to burn pits and other airborne hazards. The questions attempted to quantify the duration of exposure, the severity of acute health effects, and the relative timing of onset or worsening of chronic respiratory, cardiovascular, neurological, and other illnesses. However, the AHOBPR interview lacks specific inquiry about mental health and biomarkers. The proposed study will recruit AHOBPR participants and non-parti

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 25-70 years * Participants that reside in Arkansas * All Veterans that are deployed * Participants registered in the AHOBPR burn pit registry mainly for exposed Veterans. However, unexposed participants from the registry could also be included. * Participants not listed in the AHOBPR burn pit registry mainly for unexposed Veterans. However, exposed participants not from the registry could also be included. * Non-smokers: defined as smoke less than 10 cigarettes during lifetime. * Fluent in English Exclusion Criteria: * Any occupation and/or hobbies involves diesel exhaust, welding, paint, or other chemical fumes or organic dust * Any use of tobacco or nicotine products within the past year, such as smoking (cigarettes, pipes, cigars, e-cigarettes, vaping devices) * Self-report and/or chart review that patient is pregnant * Self-report and/or chart review that patient weight is less than 110 lbs * Participants whom the PI deems to be otherwise ineligible
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What it tests

  • Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples
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Where

1 site
Central Arkansas Veterans Healthcare System (3J/NLR)
North Little Rock, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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