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Tissue Regeneration in Patients With Chronic Obstructive Pulmonary Disease After an Exercise Intervention.

RecruitingNAAges 50 Years - 85 YearsAllUppsala University
NCT06335992 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main objective of this project is to identify mechanisms for lung regeneration in patients with COPD induced by exercise training. The hypothesis is that adjusted exercise training improves disease outcome in these patients by decrease remodelling processes linked to oxidative stress, inflammatory and/or immunological pathways in the lung. Along the way, the investigator also expect to identify (or validate) biomarkers mirroring systemic processes such as reduced inflammation and ameliorating the epithelial barrier in these patients. These events may additionally act as potential targets for interventions. Objectives (i) Evaluate biomarkers for regenerative processes, matrix turnover, stem cell activity and inflammatory patterns in lung tissue biopsies, blood- and urine samples correlated to vital lung parameters and physical capacity, before and after attending an exercise-training

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📋 Eligibility rules (as published)
Inclusion Criteria: * Forced expiratory volume in one second (FEV1) 85-30 % of predicted post bronchodilator * Optimal medical treatment according to GOLD and the Swedish National Guidelines * Absence of other significant diseases that could contribute to physical exercise limitation * Non-smoking since at least one year * Free from exacerbations (last 4 weeks) * BMI = 18- 35 Exclusion Criteria: * Regular participation in adjusted/specially designed exercise sessions * Unstable cardiovascular or pulmonary disease * Smoking * Any other criteria that at the discretion of the investigator prevent the study subject from participating in an exercise-training program
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What it tests

  • Exercise regime
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Where

2 sites
Lund University
Lund, Sweden
Uppsala University
Uppsala, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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