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An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

Recruitingn/aAges 18 Years - anyAllCity of Hope Medical Center
NCT06342414 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * A histologically confirmed diagnosis of hepatocellular carcinoma * A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma * Received standard diagnostic and staging procedures as per local guidelines * Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment Exclusion Criteria: * Lack of or inability to provide informed consent * Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma * Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma * Secondary liver cancer
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What it tests

  • ELUCIDATE
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Where

5 sites
City of Hope Medical Center
Duarte, United States
Graduate School of Medical Sciences, Kyushu University
Fukuoka, Japan
Graduate School of Medical Sciences, Kumamoto University
Kumamoto, Japan
Hokkaido University Graduate School of Medicine
Sapporo, Japan
Tokushima University
Tokushima, Japan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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