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Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke

RecruitingNAAges 18 Years - anyAllJord Vink
NCT06381388 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rationale: Acute stroke leaves many patients with functional deficits, of which upper extremity motor impairment is one of the most disabling. Evidence from imaging and electrophysiological studies converge on the idea that impaired motor function after stroke is associated with disrupted network activity in the brain. Non-invasive brain stimulation methods, like transcranial magnetic stimulation (TMS), can be used to restore disrupted network activity and have been shown to successfully facilitate recovery of motor function in patients with stroke. Application of continuous theta burst stimulation (cTBS), an inhibitory form of TMS, to the contralesional motor cortex has been shown to improve the recovery of motor function in patients with stroke. However, responsiveness to this treatment varies considerably between stroke patients and the mechanisms through which contralesional cTBS fac

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📋 Eligibility rules (as published)
Inclusion Criteria for patients: * Age ≥ 18 years; * First-ever ischemic stroke or intracerebral hemorrhage in a cerebral hemisphere or the brainstem; * Unilateral paresis of an upper extremity with a Motricity Index (MI) between 9 and 99 * Inclusion possible between 3 weeks and 6 weeks after stroke onset; * Signed informed consent. Inclusion Criteria for healthy controls: * Age ≥ 18 years; * Signed informed consent. * Normal motor function with a minimum Motricity Index (MI) of 99. Exclusion Criteria: * Disabling medical conditions (severe heart disease, severe head trauma, severe mental illness); * Severe deficits in communication, memory or understanding which could impede participation, as determined by the treating physician; * Contraindications to TMS and/or MRI (ferrous implants, history of epilepsy, drug or alcohol abuse over a period of 6 months prior to the experiment, pregnancy); * Life expectancy shorter than one year; * Upper limb paresis prior to stroke onset.
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What it tests

  • cTBS
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Where

1 site
De Hoogstraat Revalidatie
Utrecht, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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