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โ† Trials
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Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent

RecruitingNAAges 25 Years - 55 YearsAllNational Aeronautics and Space Administration (NAโ€ฆ
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In plain words

What the trial is, and whether it could suit you

The purpose of Lunar OI (Orthostatic Intolerance) is to determine if there are differences between males and females in tolerance to and cardiovascular responses during different angles of head-up tilt simulating gravity levels less than or equal to Earth's gravity. Also, this study will determine if a gradient compression garment affects tolerance to tilting and the cardiovascular stress at different tilt angles. Males and females are being identified by biological sex. This will be a two-phased study design. In Phase I we will determine whether there are differences in the development of signs or symptoms of orthostatic intolerance between males and females when tilted head up on a table to different angles to simulate gravity levels that astronauts may experience when landing on or launching from the surface of the Moon. In Phase II, the tilt tests simulating the same gravity levels f

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: โ€ข Pass a test subject screening facility modified Air Force Class III physical Exclusion Criteria: * Known allergy to furosemide or sulfa drugs * Currently taking drugs or medications known to adversely interact with furosemide, including but not limited to aspirin, NSAIDs, antibiotics, or immunosuppressant drugs * Systemic diseases or current medications known to influence the cardiovascular system * Renal disease * Type II Diabetes * Pregnant participants will be excluded (a urine pregnancy screen will be made available).
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What it tests

  • Potassium Supplement
  • Furosemide 20 MG
  • Compression Garment
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Where

1 site
NASA
Houston, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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