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Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females

RecruitingNAAges 45 Years - 75 YearsFemaleUniversity of Virginia
NCT06480695 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an intensity dependent manner. The effects of nitrate supplementation and exercise training over a longer training program remains unexplored. This investigation will examine the impact of exercise training intensity with and without inorganic nitrate supplementation, on CVD and fitness outcomes. Postmenopausal females will be tested for maximal oxygen uptake and lactate threshold before randomization

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📋 Eligibility rules (as published)
Inclusion Criteria: * Post-menopausal female (greater than age 45 but less than age 75) * Sedentary (does not exercise regularly or less than 2 bouts of exercise per week) * No major changes in medication in the last 3 months Exclusion Criteria: * Smokers within last 5 years * Weight unstable (loss/gain of more than 3kg in the past 3 months) * Any medical condition that prevents the subject from exercising safely * Hormone replacement therapy (current or within last 3 months) * Diabetes * Currently or recently on vasoactive medications (i.e., calcium channel blockers, statins, ACE or renin inhibitors, ARBs, nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, etc.) * Oral antibiotic use within previous four weeks * Oral disease or poor oral health as determined by the Oral Health Questionnaire * Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
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What it tests

  • Nitrate-Rich Beetroot Juice
  • High Intensity Exercise
  • Moderate Intensity Exercise
  • Nitrate-Depleted Placebo Beetroot Juice
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Where

1 site
Student Health and Wellness Building - Department of Kinesiology
Charlottesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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