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Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function

Recruitingn/aAges 45 Years - 55 YearsFemaleUniversity of Minnesota
NCT06490146 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a longitudinal study to determine the influence of the menopause transition on autonomic and vascular function. PI Keller-Ross has published data demonstrating that postmenopausal females have greater sympathetic neural reactivity during a stressor compared with age-matched males and younger females and males. A paucity of literature exists, however, on the role of the menopause transition in autonomic function because the majority of experimental studies on menopause physiology are cross-sectional and/or focused on older, postmenopausal females . The influence of age on HTN is robust, whereas the effects of menopause are still unclear. Preliminary data demonstrate a clear association between age and sympathetic activity in females; how the transition through menopause influences these relations, however, remains unknown. The study will enroll 80 midlife (45-55 years of age) fem

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female * age 45-55 years * premenopausal * not using any medications determined to affect autonomic function * eumenorrheic * not planning to become pregnant for the duration of participation in the study * English-speaking, literate, willing and able to provide informed consent. Exclusion Criteria: * Diabetes * pregnant or breastfeeding * cardiac or pulmonary disorders * severe obesity (body mass index \[BMI\] ≥ 40 kg/m 2 ) * hypertension * obstructive sleep apnea * current use of heart or blood pressure medications, current use of hormonal contraceptives or other forms of exogenous sex hormones * report of nicotine/tobacco use in the last six months, report of current alcohol abuse, * history of treatment with chemotherapy/radiation * coagulopathy disorders and/or use of anticoagulant medications, and current use of anxiolytics and/or antidepressants.
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What it tests

  • No intervention
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Where

1 site
University of Minnesota
Minneapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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