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68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.

RecruitingPhase 2Ages 18 Years - anyAllPeking Union Medical College Hospital
NCT06613269 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Radiation therapy (RT) is an effective treatment for patients with advanced-stage clear cell renal cell carcinoma (ccRCC). Current evidence has shown promising outcomes combining radiation therapy and standard systemic therapy in patients with metastatic/recurrent ccRCC. CAIX is a highly sensitive and specific biomarker expressed on ccRCC and in previous studies the investigators have shown excellent diagnostic efficacy of 68Ga-NY104, a CAIX-targeted PET tracer, in patients with metastatic ccRCC. In this study, the investigators aim to investigate the effect of 68Ga-NY104, and 18F-FDG PET/CT guided RT combining standard systemic therapy in patients with metastatic ccRCC.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years old * Histologically or cytologically confirmed clear cell renal cell carcinoma * Eligible for radiation therapy: no more than 10 lesions in total * Expected survival: over 3 months * ECOG: 0 or 1 * Sufficient organ function * Written informed consent Exclusion Criteria: * Brain metastasis/carcinomatous meningitis * Other malignant tumors that are not controlled within 5 years, except for non-metastatic low-risk prostate cancer. * Pregnant or breastfeeding. * Active infection.
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What it tests

  • 68Ga-NY104 PET/CT
  • 18F-FDG PET/CT
  • Radiation Therapy
  • Systemic therapy
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Where

1 site
Peking University First Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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