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AI-Driven CTA Reconstruction for Intracranial LVO

RecruitingNAAges 18 Years - 95 YearsAllShanghai Jiao Tong University Affiliated Sixth Pe…
NCT06645405 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute ischemic stroke (AIS) caused by intracranial large vessel occlusion (LVO) in the anterior circulation significantly contributes to stroke-related disability and mortality. Recent randomized controlled trials have demonstrated substantial benefits of endovascular thrombectomy (EVT) when patients are appropriately triaged beforehand. However, accurately orienting the 'missed segment' during EVT remains challenging. Guide-wires often fail to navigate through the occlusion or are mistakenly directed into the small tranches or even cause vessel rupture. To address this clinical need, the investigators developed an artificial intelligence (AI) algorithm to automate the reconstruction of CT angiography (CTA), focusing on the occluded LVO segment. To evaluate the clinical utility of this AI algorithm, the investigators propose a prospective, stepped-wedge cluster-randomized study to determ

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Male or Female, 18 years of age or older. 2. Patients who present with signs and/or symptoms concerning acute ischemic stroke. 3. Patients who undergo noncontrast CT and CT angiography imaging. 4. Patients determined to have an intracranial large vessel occlusion (including the internal carotid artery, middle cerebral artery M1 segment, and M2 segment), and eligible for endovascular treatment. Exclusion Criteria 1\) CT imaging with severe motion artifacts.
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What it tests

  • AI algorithm
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Where

2 sites
Shanghai Sixth People's Hospital
Shanghai, China
Shanghai Sixth People's Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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