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Early Amiodarone in Shockable Cardiac Arrest

RecruitingPhase 3Ages 18 Years - anyAllOregon Health and Science University
NCT06680869 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest * Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia * Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt Exclusion Criteria: * Known allergy to amiodarone * EMS-assessed contraindication to amiodarone * Pre-existing "do-not-attempt-resuscitation" orders * Inter-facility transportations * Initial care by a non-participating EMS agency able to perform advanced life support interventions * Pediatric patient as determined by EMS * Prisoners * Pregnant patients
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What it tests

  • Amiodarone Hydrochloride Injection
  • Usual Care Protocol
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Where

1 site
Oregon Health & Sciences University
Portland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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