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Speed-up the Diagnosis and Evaluation of anoMalous Coronary ARTery From the Aorta

RecruitingNAAges 6 Years - anyAllIRCCS Policlinico S. Donato
NCT06705751 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Anomalous aortic origin of the coronary arteries (AAOCA) is a rare congenital disease and one of the leading causes of sudden cardiac deaths (SCD) in young athletes but also has a lethal presentation in adult age with myocardial infarction, even if not related to obstructive coronary arteries. Unfortunately, diagnostic imaging techniques, invasive assessment, and provocative stress tests have shown low sensitivity and specificity in detecting inducible ischemia, and a multimodality assessment is then necessary. Innovative tools have been developed in the medical field using computer-based simulation, 3-dimensional reconstruction, machine learning, and artificial intelligence (AI). With the application of such new technologies, we aim to fill the gap of knowledge and the diagnostic limitation regarding risk stratification for most subjects with AAOCA. This work seeks to enhance, fasten,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult and pediatric patients (age \> 6 years) with anomalous coronary origin from the aorta (AAOCA). * Patients in spontaneous sinus rhythm. * Signed informed consent. Exclusion Criteria: * Patients with acute and chronic inflammatory conditions such as chronic liver disease, chronic kidney failure (creatinine \> 1.5 mg/dl), and thyroid disorders. * Patients with arrhythmias, absence of sinus rhythm. * Contraindications to autonomic testing. * Patients with a known allergy to materials in recording devices. * Female patients who are pregnant.
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What it tests

  • Autonomic response in AAOCA
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Where

1 site
IRCCS Policlinico San Donato
San Donato Milanese, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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