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Study on the Effect and Mechanism of Lupatadine Fumarate in the Treatment of Allergic Rhinitis

RecruitingNAAges 18 Years - 65 YearsAllCheng Lei
NCT06709092 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In China, the prevalence of allergic rhinitis reaches 17.6% and is increasing year by year, seriously affecting the quality of life of patients. Some patients still cannot be effectively treated. So it is urgent to study the pathogenesis of AR and find new therapeutic targets. Lupatadine fumarate has the dual effects of antihistamine and platelet-activating factor (PAF), and it is the only potent and highly effective allergy drug with both antihistamine and PAF antagonism currently on the marke. The exact mechanism of Lupatadine fumarate in relieving nasal congestion in patients with AR is unknown. Tight junction proteins (TJs) play an important role in maintaining endothelial barrier function, and TJ disruption disrupts barrier function and promotes inflammation. 15-LOX(15-lipoxygenase) disrupts tight junctions at the blood-brain barrier. It increases cerebral vascular permeability and

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (18-65 years). * Patients with allergic rhinitis were diagnosed based on clinical history and positive dust mite sensitization tests (skin prick test and/or specific IgE). Exclusion Criteria: * Received glucocorticoids, immunomodulatory, antihistamine drugs, and other medications that may affect the study results within the last 1 month. * Nasal diseases such as upper respiratory tract infections, chronic sinusitis with or without nasal polyps, and nasal sinus tumors. * History of nasal sinus surgery. * With other immune and allergic diseases. * Patients with a combination of severe cardiac, cerebrovascular or pulmonary - diseases, aspirin triad, primary ciliary dyskinesia, immune deficiency, and coagulation disorders. * Pregnant women. * Smokers.
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What it tests

  • lupatadine fumarate (Luso®, Yangzijiang Pharmaceuticals)
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Where

2 sites
The First Affiliated Hospital with Nanjing Medical University
Nanjing, China
The First Affiliated Hospital with Nanjing Medical University
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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