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Enhanced Protein Intake to Support Muscle Protein Synthesis in ICU

RecruitingNAAges 18 Years - anyAllMaastricht University Medical Center
NCT06714240 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rationale - Critically ill patients often experience severe skeletal muscle wasting due to an imbalance between muscle protein synthesis (MPS) and degradation, contributing to long-term impairments such as ICU-acquired weakness (ICU-AW) and post-intensive care syndrome (PICS). Effective interventions to mitigate muscle wasting remain a critical unmet need. Protein intake has been identified as a potential modulator of MPS, but anabolic resistance and conflicting evidence regarding optimal protein intake necessitate further investigation. Objective/Hypothesis - This study aims to evaluate the effect of a normal (target: 0.8 g protein/kg/day) versus elevated (target: 1.3 g protein/kg/day) protein intake on MPS rates over four days in critically ill patients. Population - 26 critically ill patients who are suitable for enteral nutrition, mechanically ventilated (min 3 days), and stay at t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged ≥ 18 years * Suitability for enteral nutrition (i.e., no GI failure, absence of complete intestinal obstruction, no major intra-abdominal sepsis) * Expected mechanical ventilation of minimal three days * Expected ICU stay of at least seven days Exclusion Criteria: * BMI ≥ 40 kg/m² * Spinal cord injury * Chronic corticosteroid use before hospital admission * severe allergies or intolerances (e.g., to cow's milk protein, fish, soy, pea protein or galactosemia) * Severe kidney and/or liver failure * Requirements for dialysis * Bleeding disorders, including anticoagulant and antiplatelet therapy
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What it tests

  • Nutritionally complete Tube Feed with standard protein levels
  • Nutritionally complete Tube Feed with higher protein levels
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Where

1 site
Jessa Hospital Campus Virga Jesse
Hasselt, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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