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Therapeutic Effect of Manuka Honey Oral Rinse in Periodontitis Patients Undergoing Hemodialysis

RecruitingPhase 3Ages 18 Years - anyAllAin Shams University
NCT06726876 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Chronic Kidney Disease (CKD) has a strong association with chronic periodontitis, an oral disease causing tooth loss linked to inflammation and malnutrition. While periodontitis affects 12.7% of the general population, its prevalence can rise to 39% in certain racial groups, and a dose-response relationship exists with CKD. End Stage Renal Disease (ESRD) patients show a prevalence of periodontitis ranging from 29% to 85.6%. Uremia, immunosuppression, and vitamin D deficiency are suggested factors in the etiology of periodontitis in CKD patients, with uremic toxins potentially altering the oral ecosystem. Periodontitis involves bacterial biofilm and Gram-negative anaerobes as primary etiological factors. The main treatment goal is to reduce periodontal pathogens and control inflammation, with non-surgical periodontal therapy (NSPT) being the standard. Although various adjuncts like antib

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Both genders, aged above 18 years. * All patients must be clinically diagnosed of ESRD undergoing hemodialysis. * All patients must have a periodontal disease. * Patients must be able to make reliable decision or communications. Exclusion Criteria: * Smoking, Alcohol. * Patient with history of any serious illness as malignancy, who undergo kidney transplant. * Patients with any autoimmune disease. * Vulnerable groups such as pregnant females, prisoners, mentally and physically handicapped individuals. * Known hypersensitivity or severe adverse effects to the treatment drugs or to any ingredient of their preparation.
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What it tests

  • Manuka honey oral rinse.
  • Normal saline rinses.
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Where

1 site
Benha hospital
Banhฤ, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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