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SNV4818 in Participants With Advanced Solid Tumors

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllPikavation Therapeutics, Inc.
NCT06736704 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is testing a new medicine, SNV4818, for people with advanced cancers. The researchers want to find out if SNV4818 is safe, well-tolerated, and effective in treating solid tumors. They are investigating different doses in order to find the safest and most effective one.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Advanced or metastatic solid tumor with an activating PIK3CA mutation. * Refractory to or intolerant of available therapies * Disease measurable by RECIST 1.1 criteria, or disease evaluable by clinically relevant tumor biomarkers in blood. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Exclusion Criteria: * Diagnosis of a primary CNS malignancy * Active brain metastases or carcinomatous meningitis * Type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus * Inadequate organ function * Clinically significant ECG abnormalities, including QTcF ≥ 470 ms
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What it tests

  • SNV4818
  • Fulvestrant
  • Palbociclib
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Where

12 sites
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate
Los Angeles, United States
Massachusetts General Hospital
Boston, United States
Thomas Jefferson University-Sidney Kimmel Cancer Center
Philadelphia, United States
Sarah Cannon Research Institute
Nashville, United States
The University of Texas M.D. Anderson Cancer Center
Houston, United States
Chris O'Brien Lifehouse
Camperdown, Australia
Scientia Clinical Research
Randwick, Australia
Monash Health
Clayton, Australia

…and 4 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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