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The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults

RecruitingNAAges 19 Years - 35 YearsAllUniversity of British Columbia
NCT06737224 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged between 19 and 35 years. * Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity). Exclusion Criteria: * History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease). * Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks). * Cigarette/vaping smoking. * Physical limitation that will impair the ability of the participant to perform exercise. * Individuals having a body mass index (BMI) over 30 kg/m2. * Cancer diagnosis in the past 5 years. * Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen). * Being unable to read or communicate in English.
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What it tests

  • Fasting + Exercise (FAST+EX): fasting + exercise condition
  • Fasting only (FAST): Non-exercise fasting condition
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Where

1 site
University of British Columbia Okanagan Campus
Kelowna, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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