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Post-line Treatment With Teniposide for c-Myc-driven Extensive-stage Small Cell Lung Cancer

RecruitingPhase 2Ages 18 Years - 75 YearsAllShanghai Pulmonary Hospital, Shanghai, China
NCT06758700 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study is being conducted to investigate the efficacy and safety of teniposide in patients with extensive-stage small cell lung cancer who have failed standard treatment and with high expression of the c-Myc-driven FBXW2/MYC gene. Based on the results, the study will explore the correlation between the expression of FBXW2/MYC and the efficacy of teniposide.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. extensive stage small cell lung cancer 2. Progression after receiving at least one chemotherapy drug treatment in the past; 3. ECOG score 0-1 4. c-Myc-driven 5. Expected survival period ≥3 months 6. Age: 18-75 years old; 7. The informed consent form complies with the ICH-GCP principles. Exclusion Criteria: 1. No measurable lesions 2. Other severe and persistent diseases or organ system dysfunction; 3. Women planning pregnancy or men planning family planning; 4. Women who are pregnant or breastfeeding; 5. Those who cannot follow the research protocol provided by the investigator.
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What it tests

  • Teniposide administration
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Where

1 site
Shanghai Pulmonary Hospital, Shanghai, China
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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