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Effect of Genetic Polymorphism on Capecitabine-Induced Toxicity in Egyptian Cancer Patients

Recruitingn/aAges 18 Years - anyAllAin Shams University
NCT06765252 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to study the effect of a single nucleotide polymorphism in the CES1 gene (rs2244613) on capecitabine-induced toxicity in Egyptian cancer patients. This study will help in understanding the interindividual variability in the CES1 gene and the effect of a single nucleotide polymorphism in this gene (rs2244613) on capecitabine-induced toxicity in participants already taking capecitabine-based chemotherapy as part of their regular medical care.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients with breast or colorectal cancer receiving capecitabine-based chemotherapy * Age \> 18 years * ECOG PS 0-2. Exclusion Criteria: * Patients treated with irinotecan * Lack of physical integrity of the upper gastrointestinal tract * Patients with malabsorption syndrome * Patients having inability to take oral medication * Patients with poor performance status * Patients with chronic diarrhea as ulcerative colitis or Crohn's disease
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What it tests

  • Capecitabine-based chemotherapy
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Where

1 site
Department of Clinical Oncology, Faculty of Medicine, Menoufia University
Shibฤซn al Kawm, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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