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Pubertal Development in Patients with RASopathies

Recruitingn/aAges 8 Years - 35 YearsAllIRCCS Azienda Ospedaliero-Universitaria di Bologna
NCT06776380 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Retrospective, single-centre, non-profit, observational study on pubertal development in patients with RASopathies. Literature data shows that puberty can be delayed by about 2 years in patients with RASopathies and this has been associated with a reduced peak growth rate. To date, only a few numerically limited case series without molecular characterisation have been published. This descriptive study should improve knowledge of pubertal development and its influence on growth and final stature. The primary aims are to describe the age of onset and progression of pubertal development in the cohort of patients with RASopathies, both male and female, and to describe the influence of pubertal development on statural growth and final stature in the same cohort.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age at enrollment between 8 and 35 years, extremes included; * Molecularly confirmed clinical diagnosis of RASopathy; * Complete pubertal development; * Obtaining informed consent for participation in the study and processing of personal data. Exclusion Criteria: • None.
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What it tests

  • Not listed
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Where

1 site
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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