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Abnormal Connectivity Involving the Social Reciprocity Network in Autism and the Impact of Neurostimulation in Mitigating the Abnormalities

RecruitingNAAges 13 Years - 18 YearsAllChristiana Care Health Services
NCT06807684 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of "social reciprocity network" and hypothesize that aberrant connectivity/oscillatory patterns affecting this network contribute to the core deficits in ASD. The overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence/spectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD.

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📋 Eligibility rules (as published)
Inclusion criteria 1\. Fulfilling the DSM-V criteria for ASD and confirmed by CARS2, HF Exclusion criteria 1. Patients with ASD exhibiting significant anxiety or contact avoidance, precluding them from cooperating with the procedure 2. Patients with a known diagnosis of seizures 3. Presence of any metallic implants or devices in the head or neck area 4. Pregnant women
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What it tests

  • transcranial magnetic stimulation
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Where

1 site
Christiana Care
Newark, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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