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To Investigate the Relationship Between the Viscoelastic Properties of the Zona Pellucida of Human Oocyte and the Blastocyst Utilization Rate

Recruitingn/aAges any - 38 YearsFemaleInti Labs
NCT06839495 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In in vitro fertilization (IVF) treatment, oocyte quality is one of the key factors influencing the success rate of fertilization. The zona pellucida (ZP) is a spherical structure that surrounds the human oocyte and, together with cumulus cells, forms the cumulus-oocyte complex (COC). These two components engage in bidirectional communication and metabolic regulation to support oocyte growth and maturation. Additionally, the physical rigidity of the zona pellucida plays an important role in the fertilization process. OPAL X1 is a non-invasive and highly safe device specifically designed to measure the viscoelastic properties of the zona pellucida. This system consists of an ultra-precise pressure control mechanism and analytical software to assess oocyte quality before fertilization. OPAL X1 applies pressure through a micropipette while simultaneously recording the movement of the zona

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Women who have started the in vitro fertilization (IVF) treatment and related examinations. 2. Female participants aged ≤38 years with an anti-Müllerian hormone (AMH) concentration greater than 1.1 ng/mL and a collected oocyte count of more than 10. 3. Participants who consent to undergoing IVF with intracytoplasmic sperm injection (ICSI) and time-lapse embryo culture. Exclusion Criteria: 1. Women diagnosed with untreated uterine abnormalities as assessed by a physician. 2. Participants with a body mass index (BMI) outside the range of 18.5-30 kg/m\^2. 3. Patients undergoing IVF using sperm retrieved through surgical extraction. 4. Patients undergoing IVF using donated oocytes or donated sperm.
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What it tests

  • Not listed
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Where

1 site
Lee Women's Hospital
Taichung, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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