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The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma

RecruitingNAAges 18 Years - anyAllOttawa Hospital Research Institute
NCT06850766 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The body's biological functions follow a circadian rhythm, meaning that individual biological functions in the body change over a 24-hour cycle. There is evidence suggesting that the body and cancer cells may react differently to anti-cancer treatment based on the time of day they are exposed. In fact, researchers have already found that giving anti-cancer treatments at a particular time of the day works better in rectal and ovarian cancer. Temozolomide (TMZ) is a chemotherapy pill/capsule commonly given to patients with newly diagnosed glioblastoma after brain surgery and radiation treatment. However, there is no current standard for what time of day TMZ should be taken for the treatment of glioblastoma. In the current study, participants are randomly placed in one of two groups: a morning group and an evening group. Based on this group placement, participants are instructed to either

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or older * Newly diagnosed IDH-wildtype glioblastoma * Completed maximal safe brain tumor resection * Completed post-operative brain RT * Plan to proceed with up to 6 cycles of adjuvant TMZ within 8 weeks of completing post-operative RT * Able and willing to provide oral informed consent Exclusion Criteria: * Unable or unwilling to complete study questionnaires * Metastatic or incurable cancer other than IDH-wild type glioblastoma
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What it tests

  • Morning administration of TMZ
  • Evening administration of TMZ
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Where

2 sites
London Health Sciences Centre
London, Canada
The Ottawa Hospital Cancer Centre
Ottawa, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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