Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques

Inclusion Criteria Clinical Inclusion Criteria 1. Males or non-pregnant females aged 18-80 years 2. Clinically diagnosed with acute coronary syndrome (including unstable angina, ST-segment elevation myocardial infarction, and non-ST-segment elevation myocardial infarction) 3. Patients willing and able to sign a written informed consent form Angiography, QFR or VFR, and OCT Inclusion Criteria 1. Successful completion of angiography, QFR or VFR, and OCT examinations 2. Successful treatment of all culprit lesions and flow-limited lesions (QFR or VFR≤ 0.8) 3. Reference vessel diameter between 2.5-4.0 mm on imaging assessment 4. Lesion length ≤40 mm 5. At least one significant stenosis (diameter reduction \>50%) demonstrated by angiography, with QFR or VFR \>0.80 and OCT-defined TCFA (fibrous cap thickness \<65μm, lipid arc \>90°) Exclusion Criteria Clinical Exclusion Criteria 1. Patients with contraindications to dual antiplatelet therapy (DAPT) or planning to discontinue DAPT within one year 2. Patients with other major illnesses and a life expectancy \<2 years 3. Patients scheduled for cardiac surgery or major non-cardiac surgery 4. Women who are breastfeeding, pregnant, or planning pregnancy during the study 5. Patients with severe heart failure (NYHA class III-IV or Killip class III-IV or left ventricular ejection fraction \<35%) 6. Patients with estimated glomerular filtration rate \<30 mL/(min·1.73 m²) 7. Patients with allergy to contrast agents or DES drugs 8. Patients currently enrolled in other clinical studies Angiographic Exclusion Criteria 1\. Patients for whom CABG is the preferred treatment 2. Target lesion is a previously stented lesion 3. Target lesion is a post-bypass lesion 4. Target lesion is a heavily calcified or angulated lesion 5. Target lesion requires dual-stent technique 6. Target lesion is a left main coronary artery lesion.