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WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

RecruitingNAAges 20 Years - 75 YearsAllUniversity of Florida
NCT06861790 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improves brain function and thinking. The study does NOT cover any costs associated with bariatric surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Between age: 20-75 yrs, English speaking, Physically mobile * Body Mass Index (BMI) \>35 kg before surgery * Compatible of MRI Scanning * Willing to give a small blood sample * Capable of providing informed consent Exclusion Criteria: * Prior or current neurological disorder * Major psychiatric disturbance * Unstable medical conditions (cancer) * MRI contraindications (claustrophobia, metal implants, waist/torso circumference)
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What it tests

  • tVNS
  • Complete Vagotomy
  • Anterior Vagotomy
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Where

1 site
University of Florida - College of Public Health and Health Professions
Gainesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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