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Phenotypic and Transcriptomic Description of Megakaryocytes in Sickle Cell Patient

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Toulouse
NCT06887907 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Sickle cell disease is the most common inherited blood disorder in the world. Chronic hemolysis induces platelet activation and chronic inflammation. Platelets and megakaryocyte, as medullar platelets precursors, are known to play a role in innate immunity. Little is known about the role of megakaryocytes at basal state and during acute complication in sickle cell disease patients. The aim of this study is to evaluate the role of megakaryocytes in sickle cell disease.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Sickle cell disease SS or S-béta° thalassemia * Patient at steady state since at least 1 year or at steady state (without crisis), or during vaso-occlusive crisis or during acute chest syndrome * Age \> 18 years old Exclusion Criteria: * Patient objects to take part in the study Hematologic disorder (leukemia, myeloma, myelodysplasic syndrome, myeloproliferative syndrome) * Immune thrombocytopenia, Immunosuppressive or anti-inflammatory (biotherapies, corticosteroids, non steroidal anti-inflammatories drugs) Page 12 sur 23 * Anti-platelets agents * Red blood cell exchange or transfusion \< 3 months
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What it tests

  • Not listed
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Where

1 site
CHU de Toulouse
Toulouse, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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