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POlycythemia, Proteins and ErYthropoiesis

Recruitingn/aAges 18 Years - anyAllCentre Hospitalier Universitaire Dijon
NCT06905106 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Erythropoiesis encompasses all the stages and mechanisms involved in the production of red blood cells, or erythrocytes, under the control of a large number of regulatory agents, most often proteins. Among these proteins, erythropoietin and interleukin-3 play a major role. Similarly, proteins involved in iron metabolism (erythroferrone, hepcidin, ferroportin, transferrin, ferritin) influence erythrocyte production more or less directly. The regulation of erythropoiesis is a fine, complex mechanism involving a large number of players, not only through the stimulation of hypoxia pathways to control erythropoietin synthesis, but also through the availability of iron, an essential element for erythropoiesis. Excessive erythrocyte production can lead to polycythemia, the causes of which are varied, primary or secondary, acquired or constitutional. The aim of this work is the descriptive study

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Persons who have given their non-opposition Patients with polycythemia: * haemoglobin value \> 16 g/dl female or \> 16.5 g/dl male * with a well-identified cause: either primary (polycythemia Vaquez, erythropoietin receptor or LNK/SH2B3 mutation...) or secondary \[cardio-respiratory pathologies, renal pathologies (post-transplant, polycystic kidney disease), metabolic pathologies, tumour (leiomyoma, pheochromocytoma...), constitutional mutations (hyperaffine haemoglobins, HIF2/EPAS1, PHD/EGLN1, VHL, ...) Patients control: \- persons with a similar pathology to that of polycythemia patients, essentialy secondary, but without polycythemia, i.e. with a haemoglobin value of \< 16 g/DL for women and \< 16.5 g/DL for men Exclusion Criteria: * Person subject to a measure of legal protection (guardianship, tutorship) * Person subject to a court order * Pregnant, parturient or nursing woman * Incapable of expressing consent * Minor
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What it tests

  • Collection of tube bottoms from blood samples taken in the clinic
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Where

1 site
CHU Dijon Bourgogne
Dijon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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