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Reproductive and Mental Health of Patients With Aplastic Anemia

Recruitingn/aAges 18 Years - 40 YearsAllInstitute of Hematology & Blood Diseases Hospital…
NCT06936930 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Aplastic anemia (AA) is a hematological disease characterized by bone marrow failure, leading to varying degrees of anemia, leukopenia, and thrombocytopenia. With the advancement of immunosuppressive therapy and hematopoietic stem cell transplantation, the survival of AA patients has significantly improved. However, these treatment approaches may result in reproductive system impairment. Reproductive health has been a major concern among reproductive-age AA patients. In female patients, it often manifests as irregular menstruation, amenorrhea, and infertility; while in male patients, it may present as reduced sperm count and low sperm motility. The reproductive impairment observed in AA patients may be attributed to various factors, including the disease's underlying pathophysiology, side effects of used medications such as androgens and the toxicity conditioning agents during transplan

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of AA * Male or female, aged 18-40 years * ECOG performance status ≤2 * Willing and able to comply with the requirements for this study and written informed consent Exclusion Criteria: * Diagnosis of inherited bone marrow failure syndromes * Combined with other hematological diseases * Chemotherapy-induced bone marrow failure * Pregnant or breastfeeding women * Subjects with a history of mental illness or severe psychological disorders * Subjects with a history of reproductive system cancer (eg, penile cancer, testicular cancer, prostate cancer, ovarian cancer, cervical cancer, vaginal cancer, etc.) * Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study
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What it tests

  • Sex hormone monitoring
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Where

1 site
Regenerative Medicine Center
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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