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Metabolic Health, Bones and Nuts During Weight Loss in Adults

RecruitingNAAges 50 Years - 75 YearsAllRutgers, The State University of New Jersey
NCT06949280 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain, and several dietary pattern studies indicate that nuts and legumes are associated with better bone health. In addition, our preliminary translational data indicates that a higher monounsaturated fatty acid (MUFA) intake is associated with improved bone mineral density (BMD) and quality. Given these findings, the proposed study aims to examine the impact of consuming peanut products on bone health, metabolic health (e.g., serum glucose, insulin, lipids and inflammatio

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and postmenopausal women (\>2 years since last menses), ages 50-75 years * Body mass index (25-42 kg/m2) or evidence of pre-clinical obesity. * Agree to be randomly assigned to consume a daily peanut snack or nut-free snack for 24 weeks * Must attend on-site visits (about 10) in New Brunswick, NJ, USA (transportation/reimbursement for travel not included) Exclusion Criteria: * Peanut allergies or intolerances * Individuals with \>5% weight loss in the past 3 months or those with extreme dietary/physical activity habits. * An inability to follow the experimental intervention or to perform the required specimen collections. * Individuals with significant psychiatric or food disorders. * Current diagnosis, or history of cancer in past 3 years. * Current diagnosis or history of bone diseases, type I or II diabetes if using insulin, gastrointestinal disease, hyperparathyroidism, Alzheimer's disease, mild cognitive impairment, untreated thyroid disease, significant immune, hepatic, cardiac, or renal disease. * History of major surgery in the past 6 months * Regular use of medications that affect bone metabolism, including bisphosphonates or hormone replacement. * Regular use of medications for cholecystitis, urinary tract infection, severe organic diseases including coronary heart disease, myocardial infarction, infectious diseases including pulmonary tuberculosis and AIDS. * Alcohol or illicit drug abuse * Any other condition deemed by the Research Physician that would prevent participation in the study, e.g. participation in another clinical research project that may interfere with the results of this study. * Participation in another clinical interventional research trial
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What it tests

  • Peanut Snack Experimental
  • Nut-free Snack
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Where

1 site
Rutgers University - NJ Inst Food Nutrition & Health
New Brunswick, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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